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Aknatm2Mak
Targeted Allele Detail
Nomenclature
Symbol: Aknatm2Mak
Name: AT-hook transcription factor; targeted mutation 2, Tak Mak
MGI ID: MGI:5788924
Synonyms: AKNA KO2
Gene: Akna  Location: Chr4:63367125-63403354 bp, - strand  Genetic Position: Chr4, 33.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:233952
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe targeting vector uses a PGK-neo cassette to disrupt exon 3, the largest coding exon. Quantitative RT-PCR studies of spleen do not detect mRNA in homozygous mutant mice. (J:233952)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akna Mutation:  37 strains or lines available
References
Original:  J:233952 Ma W, et al., Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice. Cell Res. 2011 Nov;21(11):1564-77
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory