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Aknatm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Aknatm1Mak
Name: AT-hook transcription factor; targeted mutation 1, Tak Mak
MGI ID: MGI:5788727
Synonyms: AKNA KO
Gene: Akna  Location: Chr4:63367125-63403354 bp, - strand  Genetic Position: Chr4, 33.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:233952
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Intragenic deletion
 
Mutation detailsThe targeting vector uses a PGK-neo cassette to disrupt exons 19 through 21. qRT-PCR analysis indicates that transcript expression is reduced but not completely abolished. (J:233952)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Akna Mutation:  37 strains or lines available
References
Original:  J:233952 Ma W, et al., Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice. Cell Res. 2011 Nov;21(11):1564-77
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory