Kdelr1^tm1.1Mmkm
Targeted Allele Detail

Summary

• Symbol: Kdelr1^tm1.1Mmkm
• Name: KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; targeted mutation 1.1, Masaaki Murakami
• MGI ID: MGI:5788519
• Synonyms: Kdelr1^flox
• Gene: Kdelr1 Location: Chr7:45522264-45533150 bp, + strand Genetic Position: Chr7, 29.57 cM
• Alliance: Kdelr1^tm1.1Mmkm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233546
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downsteam of exon 3. Flp-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. (J:233546)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdelr1 Mutation: 10 strains or lines available

References

• Original: J:233546 Kamimura D, et al., KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR. Nat Commun. 2015;6:7474
• All: 2 reference(s)