Dusp8^tm1Jmol
Targeted Allele Detail

Summary

• Symbol: Dusp8^tm1Jmol
• Name: dual specificity phosphatase 8; targeted mutation 1, Jeffery Molkentin
• MGI ID: MGI:5788467
• Synonyms: Dusp8 KO
• Gene: Dusp8 Location: Chr7:141633227-141649580 bp, - strand Genetic Position: Chr7, 87.59 cM, cytoband F5
• Alliance: Dusp8^tm1Jmol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233947
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 5 and 6, encoding the catalytic domain, were replaced with a neomycin resistance cassette via homologous recombination. RT-PCR analysis confirmed the absence of mRNA in the heart, brain and lung. (J:233947)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dusp8 Mutation: 24 strains or lines available

References

• Original: J:233947 Liu R, et al., DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling. Circ Res. 2016 Jul 8;119(2):249-60
• All: 5 reference(s)