Lmo7^tm1.1Chen
Targeted Allele Detail

Summary

• Symbol: Lmo7^tm1.1Chen
• Name: LIM domain only 7; targeted mutation 1.1, Ju Chen
• MGI ID: MGI:5788438
• Gene: Lmo7 Location: Chr14:101967386-102172146 bp, + strand Genetic Position: Chr14, 50.9 cM
• Alliance: Lmo7^tm1.1Chen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228772
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 14. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 14. Cre-mediated recombination removed exon 14 and the selection cassette. Western blot analysis confirmed the absence of protein expression in the adult heart. (J:228772)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmo7 Mutation: 103 strains or lines available

References

• Original: J:228772 Lao DH, et al., Lmo7 is dispensable for skeletal muscle and cardiac function. Am J Physiol Cell Physiol. 2015 Oct 1;309(7):C470-9
• All: 1 reference(s)