Il10ra^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Il10ra^tm1Flv
• Name: interleukin 10 receptor, alpha; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:5788410
• Synonyms: Il10ra^f
• Gene: Il10ra Location: Chr9:45165135-45180447 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Il10ra^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233057
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 3 was floxed. An FRT-flanked neomycin resistance cassette was also inserted into the locus. (J:233057)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il10ra Mutation: 31 strains or lines available

References

• Original: J:233057 Laidlaw BJ, et al., Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. Nat Immunol. 2015 Aug;16(8):871-9
• All: 4 reference(s)