Tex19.1^{tm4.1(Tex11)Jw}
Targeted Allele Detail

Summary

• Symbol: Tex19.1^{tm4.1(Tex11)Jw}
• Name: testis expressed gene 11; targeted mutation 4.1, Jeremy Wang
• MGI ID: MGI:5788293
• Synonyms: Tex19^KI(V749A)
• Gene: Tex11 Location: ChrX:99882254-100103245 bp, - strand Genetic Position: ChrX, 43.72 cM
• Alliance: Tex19.1^{tm4.1(Tex11)Jw} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229429
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion, Single point mutation
• Tex19.1^{tm4.1(Tex11)Jw} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tex11 (MGI:1933237)	with mutation V749A

• Mutation details: The open coding region in exon 3 was replaced with the Tex11 open reading frame with a T to C point mutation that results in the amino acid substitution of alanine for valine at position 479 (V749A). This mutation corresponds to a mutation in sterile human males. Cre-mediated recombination removed the selection cassette inserted downstream of the inserted expressed sequence. (J:229429)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tex11 Mutation: 19 strains or lines available

References

• Original: J:229429 Yang F, et al., TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse. EMBO Mol Med. 2015 Sep;7(9):1198-210
• All: 1 reference(s)