Runx1^tm9Spe
Targeted Allele Detail

Summary

• Symbol: Runx1^tm9Spe
• Name: runt related transcription factor 1; targeted mutation 9, Nancy A Speck
• MGI ID: MGI:5788255
• Synonyms: Runx1^L148A, Runx1^tm1Hdrs
• Gene: Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
• Alliance: Runx1^tm9Spe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233274
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 4 was replaced with a modified one with the amino acid substitution of alanine for lysine at position 148 (L148A). A floxed neomycin resistance cassette was inserted downstream of the modified exon 4. (J:233274)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx1 Mutation: 34 strains or lines available

References

• Original: J:233274 Soung do Y, et al., Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing. J Bone Miner Res. 2012 Jul;27(7):1585-97
• All: 1 reference(s)