About   Help   FAQ
Due to maintenance, access to MGI may be intermittent 7:30-8:30 AM EDT Thursday, May 28.
Tg(tetO-MAPT*A152T)L1Lms
Transgene Detail
Nomenclature
Symbol: Tg(tetO-MAPT*A152T)L1Lms
Name: transgene insertion L1, Lennart Mucke
MGI ID: MGI:5788163
Synonyms: hTau-A152T, TRE-hTau-A152T
Transgene: Tg(tetO-MAPT*A152T)L1Lms  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(tetO-MAPT*A152T)L1Lms expresses 1 gene
 
Mutation detailsA transgenic construct containing cDNA of the human MAPT gene encoding the 1N4R isoform, with upstream intronic sequence (from pCI-neo vector) and a Kozak sequence, and downstream bovine growth hormone polyadenylation sequence, all under the control of the tetO, tetracycline-responsive regulatory element (pTRE-Tight). The 1N4R isoform of human MAPT (microtubule associated protein tau) contains an A152T substitution, converting GCC (Ala) at positions 454-456 to ACC (Thr). Founder line C11-1, also known as founder line L1, was established. (J:233816)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:233816 Maeda S, et al., Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. EMBO Rep. 2016 Apr;17(4):530-51
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/19/2020
MGI 6.15
The Jackson Laboratory