Mfap4tm1Ascr
Targeted Allele Detail
|
Symbol: |
Mfap4tm1Ascr |
Name: |
microfibrillar-associated protein 4; targeted mutation 1, Anders Schlosser |
MGI ID: |
MGI:5787993 |
Gene: |
Mfap4 Location: Chr11:61376257-61379536 bp, + strand Genetic Position: Chr11, 37.96 cM, cytoband B2
|
Alliance: |
Mfap4tm1Ascr page
|
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: A PGK-neomycin expression cassette has replaced 1.5 kbp of the 5' non-coding region and the first 3 exons of the gene. RT-PCR analysis detects no gene transcripts and western blot analysis confirms the absence of protein expression in pulmonary tissue of homozygous mutant mice; quantitative ELISA of 2-fold diluted serum from mice detects no protein in their circulation, and immunohistochemical analysis demonstrates absence of the protein in their arterial tissue.
(J:233818)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Mfap4 Mutation: |
24 strains or lines available
|
|
Original: |
J:232534 Holm AT, et al., Characterization of spontaneous air space enlargement in mice lacking microfibrillar-associated protein 4. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1;308(11):L1114-24 |
All: |
5 reference(s) |
|