Tg(Tyr*)4794Lmon
Transgene Detail

Summary

• Symbol: Tg(Tyr*)4794Lmon
• Name: transgene insertion 4794, Lluis Montoliu
• MGI ID: MGI:5787978
• Synonyms: YRT2deltaLCR
• Transgene: Tg(Tyr*)4794Lmon Location: unknown
• Alliance: Tg(Tyr*)4794Lmon page

Transgene origin

• Strain of Origin: Hsd:ICR

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene contains a single copy of the mouse tyrosinase gene including all five exons, the 5' and 3' untranslated regions (UTRs), and ~155 kb of upstream sequence from which the locus control region (LCR), at -12 kb, has been deleted, leaving the upstream sequence intact. Transgenic mice were generated by IMYT (ICSI-mediated YAC transfer) of the 250-kb yeast artificial chromosome (YAC) YRTdeltaLCR, derived by homologous recombination of the YAC YRT2; YRT2 originated from a YAC library made from strain C3H genomic DNA. Expression of the transgene is demonstrated by its partial rescue of the pigment phenotype of albino mice. (J:211464)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:211464 Moreira PN, et al., Efficient generation of transgenic mice with intact yeast artificial chromosomes by intracytoplasmic sperm injection. Biol Reprod. 2004 Dec;71(6):1943-7
• All: 1 reference(s)