Tnfaip3^tm1.1Lpq
Targeted Allele Detail

Summary

• Symbol: Tnfaip3^tm1.1Lpq
• Name: tumor necrosis factor, alpha-induced protein 3; targeted mutation 1.1, Laura Pasqualucci
• MGI ID: MGI:5787919
• Synonyms: A20^Floxed
• Gene: Tnfaip3 Location: Chr10:18876658-18891158 bp, - strand Genetic Position: Chr10, 8.08 cM
• Alliance: Tnfaip3^tm1.1Lpq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219699
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 3. A loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:219699)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfaip3 Mutation: 44 strains or lines available

References

• Original: J:219699 Nakagawa MM, et al., Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence. J Exp Med. 2015 Feb 9;212(2):203-16
• All: 4 reference(s)