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Smyd1tm1.2Haot
Targeted Allele Detail
Summary
Symbol: Smyd1tm1.2Haot
Name: SET and MYND domain containing 1; targeted mutation 1.2, Haley O Tucker
MGI ID: MGI:5787656
Synonyms: Smyd1Floxdel
Gene: Smyd1  Location: Chr6:71190924-71239265 bp, - strand  Genetic Position: Chr6, 32.14 cM
Alliance: Smyd1tm1.2Haot page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:232969
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette was inserted downstream of exon 3. A loxP site was inserted upstream of exon 2. Cre-mediated recombination deleted the neo cassette and exons 2 and 3. The exon deletion causes a frameshift and results in a knock-out allele that phenocopies a conventional knock-out allele. (J:232969)
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smyd1 Mutation:  45 strains or lines available
References
Original:  J:232969 Rasmussen TL, et al., Smyd1 facilitates heart development by antagonizing oxidative and ER stress responses. PLoS One. 2015;10(3):e0121765
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory