Smyd1^tm1.2Haot
Targeted Allele Detail

Summary

• Symbol: Smyd1^tm1.2Haot
• Name: SET and MYND domain containing 1; targeted mutation 1.2, Haley O Tucker
• MGI ID: MGI:5787656
• Synonyms: Smyd1^Floxdel
• Gene: Smyd1 Location: Chr6:71190924-71239265 bp, - strand Genetic Position: Chr6, 32.14 cM
• Alliance: Smyd1^tm1.2Haot page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232969
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was inserted downstream of exon 3. A loxP site was inserted upstream of exon 2. Cre-mediated recombination deleted the neo cassette and exons 2 and 3. The exon deletion causes a frameshift and results in a knock-out allele that phenocopies a conventional knock-out allele. (J:232969)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smyd1 Mutation: 45 strains or lines available

References

• Original: J:232969 Rasmussen TL, et al., Smyd1 facilitates heart development by antagonizing oxidative and ER stress responses. PLoS One. 2015;10(3):e0121765
• All: 3 reference(s)