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Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Sudhansu K Dey
MGI ID: MGI:5787602
Synonyms: Rosa26Wnt5a
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:233595
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, No functional change, Reporter)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde expresses 1 gene
 
Mutation detailsThe CAG promotor, a loxP-flanked neo-stop cassette, the mouse cDNA and an FRT-flanked IRES2-AcGFP1-Nuc cassette were inserted in intron 1 of the locus. Cre expression is required to excise the neo-stop cassette and allow for expression of the gene and the nucleus-targeted GFP. Flp expression is required to remove the reporter cassette. (J:233595)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  504 strains or lines available
References
Original:  J:233595 Cha J, et al., Appropriate crypt formation in the uterus for embryo homing and implantation requires Wnt5a-ROR signaling. Cell Rep. 2014 Jul 24;8(2):382-92
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory