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Targeted Allele Detail
Symbol: Mogat1tm1Far
Name: monoacylglycerol O-acyltransferase 1; targeted mutation 1, Bob Farese
MGI ID: MGI:5785005
Gene: Mogat1  Location: Chr1:78510991-78538173 bp, + strand  Genetic Position: Chr1, 40.59 cM, cytoband C4
Germline Transmission:  Earliest citation of germline transmission: J:231617
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was replaced with a neo cassette. Deletion of this exon is predicted to result in a frame shift. Northern blot analysis confirmed expression of a smaller than normal transcript in the kidney. Enzymatic assays failed to detect MGAT activity in the kidney. (J:231617)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mogat1 Mutation:  1 strain or line available
Original:  J:231617 Agarwal AK, et al., Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice. J Lipid Res. 2016 Apr;57(4):616-30
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory