Rtn4^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Rtn4^tm1.1Arte
• Name: reticulon 4; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5784871
• Synonyms: Rtn4^flox
• Gene: Rtn4 Location: Chr11:29642947-29694331 bp, + strand Genetic Position: Chr11, 16.79 cM
• Alliance: Rtn4^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230184
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 was floxed. Flp-mediated recombination removed the selection cassette. Cre-mediated excision of exon 3 results in the specific loss of function of isoform A but not isoform B and C. (J:230184)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rtn4 Mutation: 130 strains or lines available

References

• Original: J:230184 Vajda F, et al., Cell type-specific Nogo-A gene ablation promotes axonal regeneration in the injured adult optic nerve. Cell Death Differ. 2015 Feb;22(2):323-35
• All: 3 reference(s)