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Ptger3tm1.1Brey
Targeted Allele Detail
Nomenclature
Symbol: Ptger3tm1.1Brey
Name: prostaglandin E receptor 3 (subtype EP3); targeted mutation 1.1, Richard M Breyer
MGI ID: MGI:5784744
Synonyms: EP3-
Gene: Ptger3  Location: Chr3:157566816-157644758 bp, + strand  Genetic Position: Chr3, 81.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:232822
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe targeting vector contained a loxP-flanked neo selection cassette in intron 1 and the exon coding for the beta C-terminal variant replacing the gamma variant specific sequence at the 3' end of exon 2. A third loxP site was placed downstream of the beta exon. Subsequently, cre-mediated recombination removed the neo cassette and the remainder of exon 2 and the beta exon, creating an allele that knocks out all three (alpha, beta, gamma) splice variants. (J:232822)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptger3 Mutation:  8 strains or lines available
References
Original:  J:232822 Ceddia RP, et al., The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice. Endocrinology. 2016 Jan;157(1):220-32
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory