Hsd11b1^tm1Arte
Targeted Allele Detail

Summary

• Symbol: Hsd11b1^tm1Arte
• Name: hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:5784734
• Synonyms: Hsd11b1^fl
• Gene: Hsd11b1 Location: Chr1:192903948-192946353 bp, - strand Genetic Position: Chr1, 97.67 cM
• Alliance: Hsd11b1^tm1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232825
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Out-of-frame exon 3 was flanked by loxP sites. Thus, if subjected to cre-mediated recombination, this exon would be deleted, creating a knock-out for the gene. (J:232825)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsd11b1 Mutation: 27 strains or lines available

References

• Original: J:232825 White CI, et al., Cardiomyocyte and Vascular Smooth Muscle-Independent 11beta-Hydroxysteroid Dehydrogenase 1 Amplifies Infarct Expansion, Hypertrophy, and the Development of Heart Failure After Myocardial Infarction in Male Mice. Endocrinology. 2016 Jan;157(1):346-57
• All: 2 reference(s)