Uvrag^tm1.1Tak
Targeted Allele Detail

Summary

• Symbol: Uvrag^tm1.1Tak
• Name: UV radiation resistance associated gene; targeted mutation 1.1, Tak Mak
• MGI ID: MGI:5784702
• Synonyms: UR^fl
• Gene: Uvrag Location: Chr7:98535949-98790373 bp, - strand Genetic Position: Chr7, 53.92 cM
• Alliance: Uvrag^tm1.1Tak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219272
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT- and loxP site flanked neomycin resistance cassette was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:219272)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Uvrag Mutation: 40 strains or lines available

References

• Original: J:219272 Afzal S, et al., Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1119-24
• All: 2 reference(s)