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Scram1129S4/SvJae
QTL Variant Detail
Nomenclature
QTL variant: Scram1129S4/SvJae
Name: spinal cord resistance to astrocytoma modifier 1; 129S4/SvJae
MGI ID: MGI:5784562
QTL: Scram1  Location: Chr5:138457140-138457140 bp  Genetic Position: Chr5, Syntenic
Variant
origin
Strain of Specimen:  129S4/SvJae
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:178603

Linkage analysis was performed on a mapping population of 88 (129S/Sv-Trp53tm1TyJ Nf1tm1Tyj/+ + x C57BL/6J)F1 x 129S4/SvJae mice (37 females and 51 males) to identify genomic loci related to spinal cord resistance for astrocytoma. Mice were genotyped at 880 informative SNP markers (mouse genome build 37.1; mm9).

QTL Scram1 (spinal cord resistance to astrocytoma modifier 1) maps to Chromosome 5 between 129.0 - 152.5 Mb (from 67.26 cM to the distal end of Chromosome 5) with a peak LOD score of 5.03 at 77.26 cM (rs4225536). Mice heterozygous for C57BL/6J x 129S4/SvJae at the Scram1 locus show less astrocytoma in the spinal cord compared to 129S4/SvJae homozygous mice, although authors have shown previously that 129S4/SvJae mice are more resistant to astrocytoma than C57BL/6J.

J:178603

Linkage analysis was performed on a mapping population of 88 (129S/Sv-Trp53tm1TyJ Nf1tm1Tyj/+ + x C57BL/6J)F1 x 129S4/SvJae mice (37 females and 51 males) to identify genomic loci related to spinal cord resistance for astrocytoma. Mice were genotyped at 880 informative SNP markers (mouse genome build 37.1; mm9).

QTL Scram1 (spinal cord resistance to astrocytoma modifier 1) maps to Chromosome 5 between 129.0 - 152.5 Mb (from 67.26 cM to the distal end of Chromosome 5) with a peak LOD score of 5.03 at 77.26 cM (rs4225536). Mice heterozygous for C57BL/6J x 129S4/SvJae at the Scram1 locus show less astrocytoma in the spinal cord compared to 129S4/SvJae homozygous mice, although authors have shown previously that 129S4/SvJae mice are more resistant to astrocytoma than C57BL/6J. This finding suggests that the C57BL/6J allele confers resistance to astrocytoma in the spinal cord at the Scram1 locus.

References
Original:  J:178603 Amlin-Van Schaick J, et al., Scram1 is a modifier of spinal cord resistance for astrocytoma on mouse Chr 5. Mamm Genome. 2012 Apr;23(3-4):277-85
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory