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Targeted Allele Detail
Symbol: Rorbtm2.1(tTA2)Hze
Name: RAR-related orphan receptor beta; targeted mutation 2.1, Hongkui Zeng
MGI ID: MGI:5784556
Synonyms: Rorb-2A-tTA2-D
Gene: Rorb  Location: Chr19:18930609-19111196 bp, - strand  Genetic Position: Chr19, 13.28 cM
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Allele Type:    Targeted (Transactivator)
Mutation:    Insertion
Mutation detailsThe targeting vector contains, from 5' to 3',a partial Rorb intron 9 containing an FRT3 site, a partial Ndnf exon 10 sequence up to (but not including) the endogenous stop codon, a T2A sequence that is in-frame with the Rorb coding sequence,a synthetic modified tetracycline-regulated transactivator (tTA2) gene, polyA signal, an AttB site, a PGK-Neo-polyA cassette, an FRT5 site, an mRNA splice acceptor, the 3' portion of the hygromycin gene with SV40 polyA signal, and an AttP site. PhiC31-mediated recombination removed the AttB/AttP-flanked sequence (PGK-Neo-polyA::FRT5::RNA splice acceptor::3'hygro-polyA) and replaced it with the recombined AttB/AttP site (AttL). (J:101977)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rorb Mutation:  11 strains or lines available
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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