Cldn18^tm1.1Zboro
Targeted Allele Detail

Summary

• Symbol: Cldn18^tm1.1Zboro
• Name: claudin 18; targeted mutation 1.1, Zea Borok
• MGI ID: MGI:5781137
• Synonyms: Cldn18^F
• Gene: Cldn18 Location: Chr9:99572849-99599320 bp, - strand Genetic Position: Chr9, 52.0 cM, cytoband E3-F1
• Alliance: Cldn18^tm1.1Zboro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232161
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. (J:232161)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn18 Mutation: 20 strains or lines available

References

• Original: J:232161 Li G, et al., Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Aug;51(2):210-22
• All: 1 reference(s)