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Nexntm1.1Zhh
Targeted Allele Detail
Nomenclature
Symbol: Nexntm1.1Zhh
Name: nexilin; targeted mutation 1.1, Zouhair Aherrahrou
MGI ID: MGI:5780982
Gene: Nexn  Location: Chr3:152236982-152266350 bp, - strand  Genetic Position: Chr3, 77.07 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:228046
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and downstream of exon 4. Cre-mediated recombination removed exons 2 through 4. Western blot analysis confirmed the absence of protein expression. Western blot analysis confirmed the absence of protein expression in the heart. (J:228046)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nexn Mutation:  5 strains or lines available
Notes
ES cell line = 2066 A-F9 (strain not specified)
References
Original:  J:228046 Aherrahrou Z, et al., Knock-out of nexilin in mice leads to dilated cardiomyopathy and endomyocardial fibroelastosis. Basic Res Cardiol. 2016 Jan;111(1):6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory