Acacb^tm1.1Grst
Targeted Allele Detail

Summary

• Symbol: Acacb^tm1.1Grst
• Name: acetyl-Coenzyme A carboxylase beta; targeted mutation 1.1, Gregory R Steinberg
• MGI ID: MGI:5780967
• Synonyms: Acc2-S212A KI
• Gene: Acacb Location: Chr5:114284748-114388822 bp, + strand Genetic Position: Chr5, 55.97 cM
• Alliance: Acacb^tm1.1Grst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204196
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 2 was replaced with a modified exon 2 in which nucleotide substitutions (TCT GGA to GCC GGC) that results in the amino acid substitution of alanine for serine at position 212 (S212A). Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of exon 2. (J:204196)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acacb Mutation: 111 strains or lines available

References

• Original: J:204196 Fullerton MD, et al., Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat Med. 2013 Dec;19(12):1649-54
• All: 12 reference(s)