Tg(Lcn2-Tgfa)1372Eps
Transgene Detail

Summary

• Symbol: Tg(Lcn2-Tgfa)1372Eps
• Name: transgene insertion 1372, Eric P Sandgren
• MGI ID: MGI:5780464
• Synonyms: line 1372-1, NRL-TGFalpha transgene, TgN(Nrl-tgfa)29EPS
• Transgene: Tg(Lcn2-Tgfa)1372Eps Location: unknown
• Alliance: Tg(Lcn2-Tgfa)1372Eps page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lcn2-Tgfa)1372Eps expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Tgfa (24827)

  Tgfa	(MGI:98724)

• Mutation details: The transgene contains the proximal 3-kb promoter fragment of the rat lipocalin 2 gene (also called neu-related lipocalin, Nrl) followed by a transforming growth factor alpha (Tgfa) mini-gene comprising a cDNA fragment encoding the 5' two-thirds of the the rat TGFalpha precursor joined to the rat genomic Tgfa sequence containing the 3' part of exon 4 through the beginning of the untranslated exon 6. (J:28451, J:137737)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:137737 Rose-Hellekant TA, et al., Estrogen receptor-positive mammary tumorigenesis in TGFalpha transgenic mice progresses with progesterone receptor loss. Oncogene. 2007 Aug 9;26(36):5238-46
• All: 3 reference(s)