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Transgene Detail
Symbol: Tg(Camk2a-Grin2b/Grin2a)1Jzt
Name: transgene insertion 1, Joe Z Tsien
MGI ID: MGI:5780186
Synonyms: GluN2B2A(CTR), Tg-GluN2B2A(CT), Tg-NR2B2A(CT)
Transgene: Tg(Camk2a-Grin2b/Grin2a)1Jzt  Location: unknown  
Strain of Origin:  C57BL/6J
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Camk2a-Grin2b/Grin2a)1Jzt expresses 2 genes
Mutation detailsThe transgene is designed to have ~8.5 kbp of the mouse Camk2a promoter sequences placed upstream of a chimeric NMDA glutamate receptor followed by an SV40 polyadenylation signal. Specifically, the N-terminal and transmembrane domain sequences from the rat Grin2b locus are fused with the C-terminal intracellular domain sequences from the rat Grin2a locus. Mice from the founder line with the highest expression in forebrain regions (cortex and hippocampus) were propagated. The investigator reports that Southern blots indicate only one copy of the transgene was integrated into the genome, and there is no evidence of multiple copies. (J:223086)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:223086 Jacobs S, et al., Molecular and genetic determinants of the NMDA receptor for superior learning and memory functions. PLoS One. 2014;9(10):e111865
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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