Lrrk1^tm1.2Ttfk
Targeted Allele Detail

Summary

• Symbol: Lrrk1^tm1.2Ttfk
• Name: leucine-rich repeat kinase 1; targeted mutation 1.2, Toshihiko Toyofuku
• MGI ID: MGI:5779401
• Gene: Lrrk1 Location: Chr7:65908493-66038089 bp, - strand Genetic Position: Chr7, 35.57 cM
• Alliance: Lrrk1^tm1.2Ttfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228236
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 5. An additional loxP was inserted upstream of exon 4. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 4 and 5. (J:228236)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrk1 Mutation: 78 strains or lines available

References

• Original: J:228236 Toyofuku T, et al., Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation. Mol Cell Biol. 2015 Sep 1;35(17):3044-58
• All: 1 reference(s)