Slc2a1^tm1.1Kry
Targeted Allele Detail

Summary

• Symbol: Slc2a1^tm1.1Kry
• Name: solute carrier family 2 (facilitated glucose transporter), member 1; targeted mutation 1.1, Gerard Karsenty
• MGI ID: MGI:5779367
• Synonyms: Glut1^fl
• Gene: Slc2a1 Location: Chr4:118966001-118994527 bp, + strand
• Alliance: Slc2a1^tm1.1Kry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223511
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 10. Flp-mediated recombination removed the selection cassette and left exons 3 through 10 floxed. (J:223511)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc2a1 Mutation: 63 strains or lines available

References

• Original: J:223511 Wei J, et al., Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation. Cell. 2015 Jun 18;161(7):1576-91
• All: 3 reference(s)