Trpm8^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Trpm8^tm1.1Geno
• Name: transient receptor potential cation channel, subfamily M, member 8; targeted mutation 1.1, Genoway
• MGI ID: MGI:5779285
• Gene: Trpm8 Location: Chr1:88234457-88318909 bp, + strand Genetic Position: Chr1, 44.57 cM
• Alliance: Trpm8^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223749
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 18. A loxP site was inserted downstream of exon 20. Cre-mediated recombination removed the selection cassette and exons 18 through 20, which encode the active pore domain. (J:223749)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpm8 Mutation: 60 strains or lines available

References

• Original: J:223749 Bidaux G, et al., Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner. Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):E3345-54
• All: 2 reference(s)