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Ccar2tm1Dac
Targeted Allele Detail
Nomenclature
Symbol: Ccar2tm1Dac
Name: cell cycle activator and apoptosis regulator 2; targeted mutation 1, Domenico Accili
MGI ID: MGI:5776716
Synonyms: Dbc1-
Gene: Ccar2  Location: Chr14:70138168-70153814 bp, - strand  Genetic Position: Chr14, 36.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:228688
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThe EGFP-neomycin resistance gene cassette replaced the 3' portion of exon 2. Western blot confirmed the absence of protein expression. (J:228688)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccar2 Mutation:  22 strains or lines available
References
Original:  J:228688 Qiang L, et al., Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions. Cell Rep. 2015 Jun 23;11(11):1797-808
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory