Pik3ca^tm2.1Rps
Targeted Allele Detail

Summary

• Symbol: Pik3ca^tm2.1Rps
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 2.1, Ramon Parsons
• MGI ID: MGI:5776388
• Gene: Pik3ca Location: Chr3:32451203-32520256 bp, + strand Genetic Position: Chr3, 15.7 cM, cytoband B
• Alliance: Pik3ca^tm2.1Rps page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222915
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 20 was replaced with a floxed splice acceptor/neomycin resistance cassette and a modified exon 20 in which a A to G mutation results in the amino acid substitution of arginine for histidine at position 1047 (H1047R). Cre-mediated recombination removed the selection cassette. (J:222915)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3ca Mutation: 66 strains or lines available

References

• Original: J:222915 Stratikopoulos EE, et al., Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy. Cancer Cell. 2015 Jun 8;27(6):837-51
• All: 3 reference(s)