Myd88^tm1.1Rein
Targeted Allele Detail

Summary

• Symbol: Myd88^tm1.1Rein
• Name: myeloid differentiation primary response gene 88; targeted mutation 1.1, H Christian Reinhardt
• MGI ID: MGI:5776121
• Synonyms: Myd88^c-pL252P
• Gene: Myd88 Location: Chr9:119165000-119169084 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Myd88^tm1.1Rein page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232098
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, No functional change)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting vector was designed to have a loxP site upstream of exon 2, followed by an FRT-flanked neo cassette. An F3-flanked puromycin cassette followed by a second loxP site is located downstream of exon 6. Exons 2-6 were duplicated and inserted downstream of the second loxP site, and an L252P amino acid substitution (orthologous to the human L265P mutation) was introduced into duplicated exon 5. Flp-mediated recombination removed the neo and puromycin cassettes. (J:232098)

Tumor Data

List all tumor models in MMHCdb carrying Myd88^tm1.1Rein

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myd88 Mutation: 51 strains or lines available

References

• Original: J:232098 Knittel G, et al., B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice. Blood. 2016 Jun 2;127(22):2732-41
• All: 2 reference(s)