Tg(Prnp-PRNP*6OR)K6M6Pcg
Transgene Detail

Summary

• Symbol: Tg(Prnp-PRNP*6OR)K6M6Pcg
• Name: transgene insertion K6M6, Peter Griffiths
• MGI ID: MGI:5775412
• Synonyms: Tg(KuPrP)K6M6, Tg(PRNP*)K6M6Pcg
• Transgene: Tg(Prnp-PRNP*6OR)K6M6Pcg Location: unknown
• Alliance: Tg(Prnp-PRNP*6OR)K6M6Pcg page

Transgene origin

• Strain of Origin: FVB/NIco

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-PRNP*6OR)K6M6Pcg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  kudu	PRNP	ENA Sequence: X74771.1

• Mutation details: The 12-kb transgene, derived from the pPrHG "half genomic" vector, comprises the promoter and first exon of the mouse prion protein gene (Prnp); mouse exon 2 joined to exon 3, containing the entire prion protein open reading frame, from kudu (an antelope of the genus Tragelaphus); and the 3'-untranslated region (UTR) of the mouse gene. The encoded protein contains six copies of the amino-terminal octapeptide repeat sequence (6OR), rather than the usual five copies. Mice bearing this transgene express kudu 6OR prion protein from the mouse Prnp promoter in brain and other tissues. (J:32214, J:82809, J:232471)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:232471 Veterinary Laboratories Agency, Preparation of more sensitive bioassay models for the improved detection, differentiation and diagnosis of the BSE agent. SID 5 Research Project Final Report, DEFRA Project Code SE1753. 2009
• All: 3 reference(s)