Zbp1^tm1.1Jreh
Targeted Allele Detail

Summary

• Symbol: Zbp1^tm1.1Jreh
• Name: Z-DNA binding protein 1; targeted mutation 1.1, Jan Rehwinkel
• MGI ID: MGI:5775152
• Synonyms: Zbp1^{Zalpah1alpha2}, ZBP1-Zalpha1alpha2 ^mut
• Gene: Zbp1 Location: Chr2:173048405-173060715 bp, - strand Genetic Position: Chr2, 95.83 cM, cytoband H3
• Alliance: Zbp1^tm1.1Jreh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252669
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting construct introduced several nucleotide substitutions (N46A [AAT to GCT] and Y50A [TAC to GCC] in exon 2 and N122A [AAC to GCC] and Y126A [TAT to GCT] in exon 3), that results in the amino acid substitutions of alanine for asparagine and tyrosine at positions 122 and 126 (N122A/Y126A). The final allele lacks a self-deleting neomycin resistance cassette. (J:252669)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbp1 Mutation: 28 strains or lines available

References

• Original: J:252669 Maelfait J, et al., Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis. EMBO J. 2017 Sep 1;36(17):2529-2543
• All: 3 reference(s)