Suz12^tm1.2Ijmj
Targeted Allele Detail

Summary

• Symbol: Suz12^tm1.2Ijmj
• Name: SUZ12 polycomb repressive complex 2 subunit; targeted mutation 1.2, Ian J Majewski
• MGI ID: MGI:5774816
• Synonyms: Suz12^delta
• Gene: Suz12 Location: Chr11:79883932-79924949 bp, + strand Genetic Position: Chr11, 47.36 cM
• Alliance: Suz12^tm1.2Ijmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225918
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 was flanked by loxP sites. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of exon 5. Cre-mediated recombination removed exon 5. (J:225918)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Suz12 Mutation: 60 strains or lines available

References

• Original: J:225918 Lee SC, et al., Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis. Blood. 2015 Jul 9;126(2):167-75
• All: 1 reference(s)