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Endonuclease-mediated Allele Detail
Symbol: Trem2em1Adiuj
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, MODEL-AD Center
MGI ID: MGI:5770794
Synonyms: Jax R27H ki, Trem2 R47H KI
Gene: Trem2  Location: Chr17:48653429-48659304 bp, + strand  Genetic Position: Chr17, 23.99 cM, cytoband C
Strain of Origin:  C57BL/6J
Allele Type:    Endonuclease-mediated (Humanized sequence)
Mutation:    Nucleotide substitutions
Mutation detailsThe allele was generated by injecting cas9 nuclease and a single guide RNA designed to introduce a R47H point mutation with two silent mutations (lysine AAG>AAA and alanine GCC>GCA) into the gene. (J:264639)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 35 strains available      Cell Lines: 0 lines available
Carrying any Trem2 Mutation:  59 strains or lines available
Original:  J:264639 Xiang X, et al., The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans. Mol Neurodegener. 2018 Sep 6;13(1):49
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory