Bok^tm1.1Sgk
Targeted Allele Detail

Summary

• Symbol: Bok^tm1.1Sgk
• Name: BCL2-related ovarian killer; targeted mutation 1.1, Samuel G Katz
• MGI ID: MGI:5770624
• Gene: Bok Location: Chr1:93613382-93623486 bp, + strand Genetic Position: Chr1, 47.28 cM
• Alliance: Bok^tm1.1Sgk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223399
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the translation initiation site in exon 2. An FRT-flanked puromycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. (J:223399)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bok Mutation: 21 strains or lines available

References

• Original: J:223399 Carpio MA, et al., BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7201-6
• All: 1 reference(s)