Baz1b^{tm2c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Baz1b^{tm2c(KOMP)Wtsi}
• Name: bromodomain adjacent to zinc finger domain, 1B; targeted mutation 2c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5770340
• Synonyms: Baz1b F
• Gene: Baz1b Location: Chr5:135216118-135274983 bp, + strand Genetic Position: Chr5, 75.05 cM
• Alliance: Baz1b^{tm2c(KOMP)Wtsi} page
• IMPC: Baz1b gene page

Mutation origin

• Mutant Cell Line: EPD0013_1_C02
• Germline Transmission: Earliest citation of germline transmission: J:223996
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion Vector: L1L2_gt1
• Mutation details: The L1L2_gt1 cassette was inserted at position 135237426 of Chromosome 5 upstream of the critical exon 5 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 5 at position 135238317. The critical exon 5 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:223996)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Baz1b Mutation: 80 strains or lines available

References

• Original: J:223996 Broering TJ, et al., BAZ1B is dispensable for H2AX phosphorylation on Tyrosine 142 during spermatogenesis. Biol Open. 2015;4(7):873-84
• All: 1 reference(s)