Rpe65^tm2.1Tmr
Targeted Allele Detail

Summary

• Symbol: Rpe65^tm2.1Tmr
• Name: retinal pigment epithelium 65; targeted mutation 2.1, T Michael Redmond
• MGI ID: MGI:5770317
• Synonyms: Rpe65^P25L
• Gene: Rpe65 Location: Chr3:159304812-159330958 bp, + strand Genetic Position: Chr3, 82.52 cM, cytoband H4
• Alliance: Rpe65^tm2.1Tmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223999
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 2 was replaced with one in which a T to C point mutation results in the amino acid substitution of leucine for proline at position 25 (P25L). Cre-mediated recombination removed the floxed selection cassette inserted downstream of the modified exon 2. (J:223999)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rpe65 Mutation: 51 strains or lines available

References

• Original: J:223999 Li Y, et al., Mouse model of human RPE65 P25L hypomorph resembles wild type under normal light rearing but is fully resistant to acute light damage. Hum Mol Genet. 2015 Aug 1;24(15):4417-28
• All: 1 reference(s)