Mir142^tm1.1Mpb
Targeted Allele Detail

Summary

• Symbol: Mir142^tm1.1Mpb
• Name: microRNA 142; targeted mutation 1.1, Mark P Boldin
• MGI ID: MGI:5769983
• Gene: Mir142 Location: Chr11:87647690-87647753 bp, + strand Genetic Position: Chr11, 52.21 cM
• Alliance: Mir142^tm1.1Mpb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224629
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of the microRNA sequence. An addtional loxP site was inserted downstream of the microRNA sequence. Flp-mediated recombination removed the selection cassette and left the mciroRNA sequence floxed. (J:224629)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir142 Mutation: 7 strains or lines available

References

• Original: J:224629 Kramer NJ, et al., Altered lymphopoiesis and immunodeficiency in miR-142 null mice. Blood. 2015 Jun 11;125(24):3720-30
• All: 4 reference(s)