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Akt1s1tm1.1Rrth
Targeted Allele Detail
Nomenclature
Symbol: Akt1s1tm1.1Rrth
Name: AKT1 substrate 1 (proline-rich); targeted mutation 1.1, Richard Roth
MGI ID: MGI:5769980
Gene: Akt1s1  Location: Chr7:44848991-44855421 bp, + strand  Genetic Position: Chr7, 28.94 cM, cytoband B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:231219
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted between exons 1 and 2 and after exon 5. An FRT-flanked neomycin resistance cassette was used for selection. Cre-mediated recombination removed exons 2 through 5, the entire coding region. (J:231219)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akt1s1 Mutation:  36 strains or lines available
References
Original:  J:231219 Xiong X, et al., PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways. Neurobiol Dis. 2014 Jun;66:43-52
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory