Fen1^tm4.1Bhsh
Targeted Allele Detail

Summary

• Symbol: Fen1^tm4.1Bhsh
• Name: flap structure specific endonuclease 1; targeted mutation 4.1, Binghui Shen
• MGI ID: MGI:5767325
• Synonyms: Fen1^A159V
• Gene: Fen1 Location: Chr19:10176496-10181533 bp, - strand Genetic Position: Chr19, 6.54 cM
• Alliance: Fen1^tm4.1Bhsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222783
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: The coding sequence was replaced with a floxed neomycin resistnace cassette and a modified coding sequence in which a C to T point mutation results in the amino acid substitution of valine for alanine at position 159 (A159V). This mutation has been observed in human cancers. Cre-mediated recombination removed the selection cassette. (J:222783)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fen1 Mutation: 31 strains or lines available

References

• Original: J:222783 Liu S, et al., Okazaki fragment maturation involves alpha-segment error editing by the mammalian FEN1/MutSalpha functional complex. EMBO J. 2015 Jul 2;34(13):1829-43
• All: 1 reference(s)