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Pou2f2tm1c(EUCOMM)Hmgu
Targeted Allele Detail
Nomenclature
Symbol: Pou2f2tm1c(EUCOMM)Hmgu
Name: POU domain, class 2, transcription factor 2; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:5767180
Synonyms: Pou2f2fl
Gene: Pou2f2  Location: Chr7:24786769-24879151 bp, - strand  Genetic Position: Chr7, 13.73 cM
Mutation
origin
Mutant Cell Line:  HEPD0690_4_H11
Germline Transmission:  Earliest citation of germline transmission: J:231216
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 25098260 of Chromosome 7 upstream of the critical exons 8 through 11 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exons 8 through 11 at position 25096600. The critical exons 8 through 11 are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:231216)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pou2f2 Mutation:  17 strains or lines available
References
Original:  J:231216 Hodson DJ, et al., Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2039-46
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory