Bcl3^tm2.2Sbn
Targeted Allele Detail

Summary

• Symbol: Bcl3^tm2.2Sbn
• Name: B cell leukemia/lymphoma 3; targeted mutation 2.2, Ulrich Siebenlist
• MGI ID: MGI:5767145
• Gene: Bcl3 Location: Chr7:19542387-19556691 bp, - strand Genetic Position: Chr7, 9.95 cM
• Alliance: Bcl3^tm2.2Sbn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231214
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the start codon in exon 1. A tandem affinity purification (TAP) tag was inserted downstream of the start codon. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downsteam of exon 1. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 1 floxed. (J:231214)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl3 Mutation: 57 strains or lines available

References

• Original: J:231214 Tassi I, et al., The NF-kappaB regulator Bcl-3 governs dendritic cell antigen presentation functions in adaptive immunity. J Immunol. 2014 Nov 1;193(9):4303-11
• All: 1 reference(s)