Sirpa^tm1.2Mato
Targeted Allele Detail

Summary

• Symbol: Sirpa^tm1.2Mato
• Name: signal-regulatory protein alpha; targeted mutation 1.2, Takashi Matozaki
• MGI ID: MGI:5767142
• Gene: Sirpa Location: Chr2:129434755-129474148 bp, + strand Genetic Position: Chr2, 63.19 cM, cytoband F3
• Alliance: Sirpa^tm1.2Mato page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230340
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination deleted part of exon 2 and intron 2 floxed. (J:230340)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirpa Mutation: 37 strains or lines available

References

• Original: J:230340 Washio K, et al., Dendritic cell SIRPalpha regulates homeostasis of dendritic cells in lymphoid organs. Genes Cells. 2015 Jun;20(6):451-63
• All: 4 reference(s)