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Tg(ACTA1-Ctss)1Jmol
Transgene Detail
Nomenclature
Symbol: Tg(ACTA1-Ctss)1Jmol
Name: transgene insertion 1, Jeffery Molkentin
MGI ID: MGI:5765989
Synonyms: Ctss Tg
Transgene: Tg(ACTA1-Ctss)1Jmol  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(ACTA1-Ctss)1Jmol expresses 1 gene
 
Mutation detailsThe transgene consists of a Ctss cDNA sequence under the control of a modified human ACTA1 promoter, which is active in skeletal muscle. Western blot analysis confirms overexpression in multiple skeletal muscles that are predominantly fast-twitch, with lower levels of expression in soleus (slow-twitch). Founder line 1 is the higher expressing transgenic line. (J:230788)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:230788 Tjondrokoesoemo A, et al., Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice. J Biol Chem. 2016 May 6;291(19):9920-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory