Rps6kb1^tm1.1With
Targeted Allele Detail

Summary

• Symbol: Rps6kb1^tm1.1With
• Name: ribosomal protein S6 kinase, polypeptide 1; targeted mutation 1.1, Dominic J Withers
• MGI ID: MGI:5763789
• Synonyms: Rps6kb1^fl, S6k1^f
• Gene: Rps6kb1 Location: Chr11:86389697-86435631 bp, - strand Genetic Position: Chr11, 51.82 cM
• Alliance: Rps6kb1^tm1.1With page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228388
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exons 3 and 4 floxed. (J:228388)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rps6kb1 Mutation: 56 strains or lines available

References

• Original: J:228388 Smith MA, et al., Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice. Cell Rep. 2015 Apr 21;11(3):335-43
• All: 2 reference(s)