Ccn1^tm4Lfl
Targeted Allele Detail

Summary

• Symbol: Ccn1^tm4Lfl
• Name: cellular communication network factor 1; targeted mutation 4, Lester F Lau
• MGI ID: MGI:5763569
• Synonyms: Ccn1^D125A
• Gene: Ccn1 Location: Chr3:145352731-145355736 bp, - strand Genetic Position: Chr3, 70.18 cM
• Alliance: Ccn1^tm4Lfl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222419
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucelotide substitution results in the amino acid substitution of alanine for aspartic acid at position 125 (D125A). This mutation disrupts integrin binding. (J:222419)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ccn1 Mutation: 33 strains or lines available

References

• Original: J:222419 Kim KH, et al., CCN1 induces hepatic ductular reaction through integrin alphavbeta(5)-mediated activation of NF-kappaB. J Clin Invest. 2015 May;125(5):1886-900
• All: 3 reference(s)