Musk^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Musk^tm1.1Ics
• Name: muscle, skeletal, receptor tyrosine kinase; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5763563
• Synonyms: MuSK^flox(CRD)
• Gene: Musk Location: Chr4:58285962-58374303 bp, + strand Genetic Position: Chr4, 31.87 cM
• Alliance: Musk^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221340
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/cN

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A self-excising neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 9. An additional loxP site was inserted downstream of exon 11. The final allele lacks the selection cassette with exons 9 through 11 floxed. (J:221340)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Musk Mutation: 42 strains or lines available

References

• Original: J:221340 Messeant J, et al., MuSK frizzled-like domain is critical for mammalian neuromuscular junction formation and maintenance. J Neurosci. 2015 Mar 25;35(12):4926-41
• All: 1 reference(s)