Syk^tm1.1Beni
Targeted Allele Detail

Summary

• Symbol: Syk^tm1.1Beni
• Name: spleen tyrosine kinase; targeted mutation 1.1, Bernhard Nieswandt
• MGI ID: MGI:5763403
• Synonyms: Syk^fl
• Gene: Syk Location: Chr13:52737209-52802828 bp, + strand Genetic Position: Chr13, 27.41 cM, cytoband B-C2
• Alliance: Syk^tm1.1Beni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224116
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:224116)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syk Mutation: 45 strains or lines available

References

• Original: J:224116 Lorenz V, et al., Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization. Blood. 2015 Jun 25;125(26):4069-77
• All: 5 reference(s)